HS-LS1-6: Formation of Carbon-Based Molecules

Construct and revise an explanation based on evidence for how carbon, hydrogen, and oxygen from sugar molecules may combine with other elements to form amino acids and/or other large carbon-based molecules. (Energy and Matter)

Clarification Statement: Emphasis is on using evidence from models and simulations to support explanations.

Assessment Boundary: Assessment does not include the details of the specific chemical reactions or identification of macromolecules.


The following assessments were created by science teachers hoping to better understand the NGSS. In most cases teachers went from standard to assessment in around an hour.  These are drafts and should be used accordingly. Feel free to improve these assessments or contribute to the collection. Learn more about assessment design here.




Hydrocarbon backbones
Chemical reactions
Amino acids
Carbon-based molecules (e.g. proteins, DNA)
Energy and Matter
New cells


Learning Plans


*Next Generation Science Standards is a registered trademark of Achieve. Neither Achieve nor the lead states and partners that developed the Next Generation Science Standards were involved in the production of this product, and do not endorse it.  Visit the official NGSS website.